What is the relationship between rheumatoid arthritis and neuropathy?
RA is primarily known for affecting joints, but it can also impact the nervous system. Nearly 50% of people with RA may develop peripheral neuropathy — a condition where nerves outside the brain and spinal cord become damaged, disrupting signals to muscles Show Full Answer
What is the relationship between rheumatoid arthritis and neuropathy?
RA is primarily known for affecting joints, but it can also impact the nervous system. Nearly 50% of people with RA may develop peripheral neuropathy — a condition where nerves outside the brain and spinal cord become damaged, disrupting signals to muscles and skin. Common symptoms of peripheral neuropathy include:
- Numbness or tingling in fingers or toes
- Pins-and-needles sensations
- Muscle weakness or twitching
- Increased sensitivity or nerve pain Several RA-related factors can trigger neuropathy:
- Anti-CCP antibodies — immune proteins linked to RA that are associated with nerve damage
- Nerve entrapment — swollen joints compressing nearby nerves (e.g., carpal tunnel syndrome)
- Vasculitis — inflamed blood vessels reducing blood flow to nerves
- RA medications — some treatments, including leflunomide and anti-TNF-alpha drugs, have been linked to neuropathy in some people
A myRAteam member shared that their doctor identified neuropathy as a side effect of leflunomide, and symptoms improved after stopping it. The good news is that treating the underlying RA with DMARDs can help prevent or relieve neuropathy symptoms. Additional options may include medications like gabapentin or pregabalin for nerve pain, or procedures like TENS therapy.
Always flag any new numbness, tingling, or weakness to your healthcare provider early — catching it sooner makes it easier to manage.
October 10
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