How does immune function relate to rheumatoid arthritis?
RA is actually the result of an overactive immune system, not a deficient one. With RA, the immune system mistakenly attacks healthy joint tissue instead of harmful invaders like bacteria or viruses. This causes chronic inflammation, pain, and over time, joint Show Full Answer
How does immune function relate to rheumatoid arthritis?
RA is actually the result of an overactive immune system, not a deficient one. With RA, the immune system mistakenly attacks healthy joint tissue instead of harmful invaders like bacteria or viruses. This causes chronic inflammation, pain, and over time, joint damage.
Two key antibodies are involved in this process:
- Rheumatoid factor (RF) — an antibody that targets healthy tissue
- Anti-CCP — another autoantibody linked to RA development However, RA treatments can affect immune function. Many medications used to manage RA — such as DMARDs, biologics, and corticosteroids — work by suppressing the immune system to reduce inflammation. This can make the body less able to fight off infections.
Because of this, it's important to:
- Stay up to date on recommended vaccines (like the flu shot and pneumonia vaccine)
- Let your rheumatologist know if you feel unwell or notice signs of infection
- Have regular check-ins with your care team to monitor how your treatment is affecting your immune response
It's a bit of a balancing act — calming an overactive immune system without leaving the body too vulnerable. Your rheumatologist is the best person to help find that balance.
August 27
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