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Richland, NY
August 24
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Are colds more common or harder to deal with when taking methotrexate?

Methotrexate works by suppressing the immune system, which can make it harder for the body to fight off infections — including common colds. This means catching colds may happen more easily, and they can sometimes linger longer than usual. Some Show Full Answer

Are colds more common or harder to deal with when taking methotrexate?

Methotrexate works by suppressing the immune system, which can make it harder for the body to fight off infections — including common colds. This means catching colds may happen more easily, and they can sometimes linger longer than usual. Some cold-like symptoms can actually be side effects of methotrexate itself. These include:

- Stuffy or runny nose
- Sneezing
- Cough or hoarseness
- Ear congestion

These occur in roughly 10% of people taking methotrexate, so it can sometimes be tricky to tell whether it's a cold or the medication at work. To help reduce the risk of catching colds or infections while on methotrexate, some helpful habits include:

- Washing hands frequently
- Covering your mouth when coughing or sneezing
- Avoiding sharing personal items like towels or razors
- Wearing a mask in crowded public spaces
- Staying up to date on vaccinations (always check with your doctor first) If a cold develops into something more serious, like a sinus infection, it's important to contact a doctor promptly. Because methotrexate lowers immune function, infections that go untreated can become more serious. Never stop or adjust methotrexate on your own — always consult a rheumatologist first.

August 24

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