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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Acute pain

A myRAteam Member asked a question 💭
Pennsylvania Furnace, PA

What can be safely taken for acute pain while taking MTX?

August 19
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myRAteam

Managing acute pain with RA can feel overwhelming, but there are several approaches that may help bring relief. The key is combining good RA disease management with targeted pain relief strategies.

Here are some options to consider:

- Over-the-counter pain relievers – Medications like acetaminophen (Tylenol) or NSAIDs Show Full Answer

Managing acute pain with RA can feel overwhelming, but there are several approaches that may help bring relief. The key is combining good RA disease management with targeted pain relief strategies.

Here are some options to consider:

- Over-the-counter pain relievers – Medications like acetaminophen (Tylenol) or NSAIDs such as ibuprofen or naproxen can help with mild to moderate pain
- Topical treatments – Creams, gels, or patches applied to the skin can offer localized relief
- Heat therapy – Heating blankets, warm showers, hot tea, rice bags, or space heaters can ease joint pain and stiffness
- Cold therapy – Applying something cold to swollen joints may also reduce inflammation and discomfort
- Stay warm – Keeping joints warm, especially in cold weather, can prevent pain from worsening

One myRAteam member shared, "If the pain is really bad, I will also take a Tylenol, wait 45 minutes, and take a second one if it is still hurting." For more persistent or severe acute pain, a rheumatologist may suggest corticosteroids like prednisone for short-term relief. A pain management specialist can also be a valuable addition to your care team.

Always check with your doctor before adding any new medications or therapies to your routine — even over-the-counter ones. Getting your RA well-controlled is ultimately the best long-term strategy for reducing acute pain episodes.

August 19
A myRAteam Member

Hi. Perhaps you could ask for the prescription drug Celebrex. It’s an anti-inflammatory medication. It has risks associated with it, as every drug does, but it may help you. Pain is miserable. I hope you get relief soon!

August 19
A myRAteam Member

I agree with that summary. I’ve been told that MTX and NSAIDS do not mix. I was only on MTX for 5 weeks when first diagnosed and it did nothing for me. I now take Luflunomide which may be starting to work but it usually takes 6-8 weeks to hit it therapeutic level. I can safely mix Ibuprofen and Acetaminophen with it. I also have a muscle relaxer for spasms and cramps at bedtime. I have a new pain management clinic and will see how they suggest handling it. Unfortunately I also have Osteoarthritis🤯🤪

August 19

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