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Yes, this is something others have experienced too — and it can be really frustrating when a medication that's been working suddenly starts causing problems. Stomach issues are actually one of the most common side effects of methotrexate (MTX), affecting anywhere from 20% to 65% of people with RA who take it.

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Yes, this is something others have experienced too — and it can be really frustrating when a medication that's been working suddenly starts causing problems. Stomach issues are actually one of the most common side effects of methotrexate (MTX), affecting anywhere from 20% to 65% of people with RA who take it.

Common gastrointestinal side effects include:

- Nausea and vomiting
- Diarrhea
- Bloating
- Stomach discomfort Even if these symptoms appear after years on the medication, there are some strategies that may help manage them:

- Taking MTX after a full meal
- Scheduling the dose on a Friday or Saturday to recover over the weekend
- Taking a folic acid supplement
- Using other medications to manage nausea

The most important thing is to let your rheumatologist know what's going on. Don't stop taking MTX without talking to them first — stopping suddenly could cause an RA flare. They can help figure out whether the stomach issues are from the MTX or something else, and adjust your treatment plan if needed.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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