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Could Orencia be causing UTI-like symptoms even without an actual infection? This is a really valid concern, and it's worth understanding the connection.

Orencia (abatacept) is a biologic DMARD that works by suppressing parts of the immune system to reduce inflammation. Because it affects immune function, it can increase Show Full Answer

Could Orencia be causing UTI-like symptoms even without an actual infection? This is a really valid concern, and it's worth understanding the connection.

Orencia (abatacept) is a biologic DMARD that works by suppressing parts of the immune system to reduce inflammation. Because it affects immune function, it can increase the risk of urinary tract infections — and may also cause UTI-like symptoms even when no infection is present. Many RA medications that suppress the immune system carry a similar risk for UTI symptoms. It's not uncommon for people on biologics like Orencia to experience these uncomfortable symptoms.

A myRAteam member shared a similar experience while on methotrexate, saying they seemed to have a "never-ending UTI."

Here are some important steps to consider:

- Tell your rheumatologist about these symptoms — they need to know, as they may adjust or temporarily pause your Orencia
- Don't ignore ongoing discomfort — untreated urinary symptoms can sometimes lead to more serious complications
- Ask about alternative explanations — your rheumatologist may want to investigate further

It's great that infections have been ruled out, but the discomfort still deserves proper attention. Pushing for answers from your rheumatologist — not just the urologist — may get better results since they understand how Orencia interacts with your immune system.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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