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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

How long does the generic Humira take to work?

A myRAteam Member asked a question 💭
Clarinda, IA
August 4
 · 
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Answer Summary

Members discussed how long the generic Humira (adalimumab) takes to work, with one member sharing it took about 2 to 3 months before noticing... Read more

Members discussed how long the generic Humira (adalimumab) takes to work, with one member sharing it took about 2 to 3 months before noticing results. Several members described a familiar pattern where biologics work well for a time but eventually lose effectiveness, especially after breaks in treatment such as surgeries. A highlight was one member's encouraging success story with Hadlima, a biologic similar to Humira, which they felt worked quickly due to already having Enbrel in their system, sparking hope and curiosity among others in the thread.

A myRAteam Member

I don't remember when I was on it. It did work for me for less than a year, and I had to change. Every med I have taken has been the same, work for a while but then is tapers off.

August 4
myRAteam

Great question! The generic versions of Humira (adalimumab biosimilars) work the same way as the original, as they belong to the TNF-alpha inhibitor class of biologics.

Biologics like adalimumab typically start showing effects within 2 to 6 weeks, with some people noticing changes even within a few days of the first dose.

Show Full Answer

Great question! The generic versions of Humira (adalimumab biosimilars) work the same way as the original, as they belong to the TNF-alpha inhibitor class of biologics.

Biologics like adalimumab typically start showing effects within 2 to 6 weeks, with some people noticing changes even within a few days of the first dose.

Full effectiveness is usually reached around 12 weeks after starting treatment. Everyone's experience is a little different though. A myRAteam member shared that their biologic "took several weeks to start working," while another said it took closer to six months to feel the full benefit.

A few important things to keep in mind:

- Biologics are often prescribed alongside conventional DMARDs like methotrexate to boost effectiveness
- The biggest risk with biologics is increased infection risk, so staying up to date on vaccines is important
- Always talk to your rheumatologist if you feel like the medication isn't working as expected — they may adjust your dose or treatment plan

August 4
A myRAteam Member

If it is adalimumab-xyzab it has the same thing as Humira. Adalimumab has brand similars.

I start my second brand similar this week since my insurance will not sponsor Humira or the first similar I was on.

August 9 (edited)
A myRAteam Member

Hi I am on the generic of humaira I don’t think it’s working at all now but it took about 2-3 months to start to work. Worked well until I needed to be off for a month due to hip replacement so quiet in mid June started again in mid July but the flares are one after another. I have two more surgeries coming this fall so I’ll be off again 2 x s As soon as I’m able to go back on I’ll ask the dr to change it.
Take care Hugs

August 5
A myRAteam Member

Same here! Do they give you a reason why? Have you found anything lately that works?

August 5

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