Rinvoq (upadacitinib) is a once-daily, extended-release tablet approved for adults with RA who don't tolerate or respond well to methotrexate. It can be taken alone or combined with methotrexate, and it works by blocking a signaling protein called JAK1. When it comes to side effects, here are a few things worth knowing:
- Show Full Answer
Rinvoq (upadacitinib) is a once-daily, extended-release tablet approved for adults with RA who don't tolerate or respond well to methotrexate. It can be taken alone or combined with methotrexate, and it works by blocking a signaling protein called JAK1. When it comes to side effects, here are a few things worth knowing:
- Weight changes are possible — Rinvoq didn't cause weight gain in RA clinical trials, but the makers do list "increased weight" as a potential side effect
- Other side effects should always be reported to your rheumatologist, who may adjust your dose or switch medications
- Keeping a symptom and side effect journal can be really helpful for tracking how you're feeling and discussing it at appointments
If Rinvoq is significantly improving your RA symptoms and joint pain, that benefit may outweigh some manageable side effects — but that's always a conversation to have with your rheumatologist. Many myRAteam members have shared that feeling heard by their doctor makes a big difference in navigating treatment decisions. Don't hesitate to speak up if something doesn't feel right — you deserve a rheumatologist who listens and works with you on a plan.
August 3
Join
Your Privacy Choices
