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A myRAteam Member asked a question 💭
July 29
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Great question — and one that other myRAteam members have wondered about too! The short answer is: body odor is not a known or documented side effect of methotrexate.

That said, some side effects of methotrexate *could* indirectly affect how you smell — or how you perceive smells. Here are a few ways this might happen:

- Show Full Answer

Great question — and one that other myRAteam members have wondered about too! The short answer is: body odor is not a known or documented side effect of methotrexate.

That said, some side effects of methotrexate *could* indirectly affect how you smell — or how you perceive smells. Here are a few ways this might happen:

- Increased sweating — Though uncommon, sweating is a possible side effect of methotrexate. Since body odor comes from sweat mixing with bacteria on the skin, more sweating could change your scent.
- Changes in liver function — Liver damage is a rare but serious side effect of methotrexate, and liver issues can sometimes be linked to changes in body odor.
- Altered sense of smell — Methotrexate can affect your sense of smell, which might make you *perceive* a change in body odor even if there isn't one. If you're noticing changes and are concerned, it's always worth mentioning to your rheumatologist. They can help figure out whether it's related to the medication or something else entirely.

July 29

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