Just fatigue. The only issue is I take wegovy orally. Dr thinks it’s keeping MTX from working. Dr is switching me to injection.
August 1
Hi Cheryl,
I take the Rasuvo once a week. It has worked well for me, no side effects, and I prefer this to the pills. Are you experiencing side effects?
August 1
Switching from oral methotrexate (MTX) to an injectable form is actually pretty common, and there are two main auto-injector pen brands available:
- Rasuvo
- Otrexup
Both come as single-dose auto-injectors, prefilled with your prescribed dose, and have a hidden needle — so no scary needle-in-view moment! They deliver the Show Full Answer
Switching from oral methotrexate (MTX) to an injectable form is actually pretty common, and there are two main auto-injector pen brands available:
- Rasuvo
- Otrexup
Both come as single-dose auto-injectors, prefilled with your prescribed dose, and have a hidden needle — so no scary needle-in-view moment! They deliver the medication just under the skin with minimal pain. The side effects for injectable MTX are very similar to the oral form. The most common ones include:
- Nausea, vomiting, or diarrhea
- Mouth sores
- Fatigue or brain fog
- Occasional hair loss (less common at typical RA doses)
Some myRAteam members have actually found the injectable form easier on side effects — one member noted side effects lasted less than 24 hours before feeling great the rest of the week. One key benefit of injections is better absorption compared to oral pills, which can mean better effectiveness for managing RA symptoms.
Taking folic acid daily (often 1mg, as prescribed) can help reduce gastrointestinal side effects and mouth sores. Always discuss any new or worsening side effects with your rheumatologist, who will also monitor your liver function through routine blood tests.
July 27
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