Both Orencia (abatacept) infusions and subcutaneous (under-the-skin) injections work the same way — by blocking immune cell activation to reduce inflammation and joint damage. The main differences come down to how and how often they're given, rather than how well they work.
Here's a quick comparison:
Infusions
- Given at Show Full Answer
Both Orencia (abatacept) infusions and subcutaneous (under-the-skin) injections work the same way — by blocking immune cell activation to reduce inflammation and joint damage. The main differences come down to how and how often they're given, rather than how well they work.
Here's a quick comparison:
Infusions:
- Given at a clinic or infusion center
- Administered once a month after the initial doses
- Initial doses are given at the start, then at 2 weeks and 4 weeks
- Each session lasts 30–60 minutes
Weekly Shots:
- Self-administered at home
- Given once a week
- More convenient but requires more frequent dosing Improvements with either method can be seen within about 3 months, and benefits can continue throughout the first year of treatment.
One myRAteam member shared: *"I have been on and off Orencia for years. It works well, and I have no side effects from it."*
The best option really depends on personal preference — whether the convenience of home injections outweighs the less frequent clinic visits for infusions. It's worth having a detailed conversation with a rheumatologist to figure out which fits best with lifestyle and treatment goals.
June 15
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