Switching biologics can feel daunting, but Orencia (abatacept) is a well-established option for RA. It works differently from Enbrel — instead of targeting TNF, it blocks a signal between immune cells (called costimulation) that triggers inflammation.
Here's what to generally expect with Orencia auto-injections:
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Switching biologics can feel daunting, but Orencia (abatacept) is a well-established option for RA. It works differently from Enbrel — instead of targeting TNF, it blocks a signal between immune cells (called costimulation) that triggers inflammation.
Here's what to generally expect with Orencia auto-injections:
- It's given as a weekly subcutaneous (under the skin) injection
- Improvements may be noticed within about 3 months
- Benefits can continue to build throughout the first year of treatment
- Common injection site reactions include redness, itching, or swelling, which often settle down after a few injections One myRAteam member shared their experience: "I was resistant and scared at first, but was in enough misery to give it a try after going through so many drugs that worked, then stopped. It works well, and I have no side effects from it."
A few tips for making auto-injections more comfortable:
- Ice the injection site before and after to reduce pain or swelling
- Let the alcohol dry completely before injecting
- Rotate injection sites (thigh, abdomen, or arm) to avoid soreness or scar tissue buildup
- Inject quickly for less discomfort
Always check with your rheumatologist about any reactions or concerns as you get started. Hang in there — transitions like this take a little time! 💪
May 29
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