Whether switching from Humira (adalimumab) injections to Rinvoq (upadacitinib) tablets is a positive move really depends on your individual situation. These are two very different types of medications, so it's worth understanding how they differ.
Humira is a biologic that works by targeting a specific inflammatory protein Show Full Answer
Whether switching from Humira (adalimumab) injections to Rinvoq (upadacitinib) tablets is a positive move really depends on your individual situation. These are two very different types of medications, so it's worth understanding how they differ.
Humira is a biologic that works by targeting a specific inflammatory protein called TNF-alpha. It's given as a subcutaneous (under the skin) injection.
Rinvoq is a JAK inhibitor — an oral, once-daily extended-release tablet. It works by blocking JAK1 signaling proteins that drive inflammation. Rinvoq is typically prescribed when someone hasn't responded well to, or can't tolerate, methotrexate or biologics like Humira. So if Humira isn't controlling your RA effectively, a switch to Rinvoq could make sense.
Some potential considerations include:
- Convenience — swapping injections for a daily pill can feel like a win (no more needle days! 🎉)
- Effectiveness — Rinvoq may work better for some people whose RA hasn't responded to TNF inhibitors like Humira
- Side effects — both medications suppress the immune system, increasing infection risk, so monitoring is important
- Safety profile — JAK inhibitors like Rinvoq carry specific risks that your rheumatologist will want to discuss with you
The most important step is having an open conversation with your rheumatologist about why the switch is being considered and what to expect during the transition.
May 25
That's good. He's paying attention.
May 27
Humira is not working well enough for me. So Dr said it's time to change it.
May 26
No Carol it’s not working! I take the injection on Thursday and by Saturday it’s building. By Wednesday I’m a wreck. Dr said doesn’t want to change it as after the surgeries I’ll need a new drug. I’m just very thankful that the Leflunimide is working
Eating is very hard I manage a little yogurt and berries for breakfast and a piece of toast and that’s my intake of nutrients for the day.
Hugs
May 26
It didn't work for me, but hopefully it will for you. So the Humira isn't working for you?
May 26
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