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Hair loss is a known side effect of methotrexate, and it's understandable to want to manage it. Methotrexate works by blocking folate, which affects fast-growing cells — including hair follicles. The good news is that hair loss from methotrexate is usually mild and often improves over time.

Here are some steps that may Show Full Answer

Hair loss is a known side effect of methotrexate, and it's understandable to want to manage it. Methotrexate works by blocking folate, which affects fast-growing cells — including hair follicles. The good news is that hair loss from methotrexate is usually mild and often improves over time.

Here are some steps that may help:

- Ask your doctor about folic acid supplements — these are commonly recommended alongside methotrexate and may help reduce hair loss
- Be gentle when brushing or combing — less frequent brushing and a lighter touch can reduce breakage
- Avoid tight hairstyles — constant tension can worsen hair loss and may even cause permanent damage
- Discuss your dosage — your rheumatologist may consider adjusting your methotrexate dose if hair loss is significant

If you notice large clumps falling out suddenly or patchy hair loss, contact your healthcare provider right away. Some myRAteam members have shared similar experiences — one noted losing 50% of their hair on methotrexate, while others described texture changes alongside thinning. You're definitely not alone in this.

It's worth having an open conversation with your rheumatologist, who can help determine the best path forward for your treatment plan.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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