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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myRAteam Member asked a question 💭
Oakland, MD

I was diagnosed with RA all labs for RA, anti-cop, Ana, sedrate all positive. Now after 11 years all are negative or in normal range. I don’t understand!

April 14
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A myRAteam Member

Because still have symptoms they want to say I have fibromyalgia and prescribed cymbalta. Should just be seronegative RA

April 14
myRAteam

How can seropositive RA become seronegative?

It's understandable to feel confused about this change! While it's less common, antibody levels can fluctuate over time, especially with effective treatment.

Here are some possible explanations:

- Treatment success: Disease-modifying medications may have reduced inflammation Show Full Answer

How can seropositive RA become seronegative?

It's understandable to feel confused about this change! While it's less common, antibody levels can fluctuate over time, especially with effective treatment.

Here are some possible explanations:

- Treatment success: Disease-modifying medications may have reduced inflammation so effectively that antibody production decreased to undetectable levels
- Disease remission: Your RA may be in a period of low or minimal disease activity
- Natural fluctuation: Antibody levels can vary over time, and some people's levels may drop below detectable ranges

The normal sed rate and other markers suggest your inflammation is well-controlled, which is actually great news! This doesn't necessarily mean your RA has disappeared, but rather that it's being managed effectively.

It's important to discuss these results with your rheumatologist. They can help interpret what this means for your specific situation and whether any adjustments to your treatment plan are needed. Some people maintain remission with continued treatment, while others may need ongoing monitoring.

April 14

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