You should use Magnesium Biglycinat.
------------------------------
## 1. The Methotrexate Paradox: Treating RA but Damaging the Gut

* The Goal: MTX is a folate antagonist. It slows down rapidly dividing cells to suppress the overactive immune system causing your RA joint inflammation. [1, 2, 3, 4, 5]
* The Collateral Damage: The cells lining your gut (enterocytes) are also among the fastest-dividing cells in the body. MTX accidentally targets them too.
* The Result: This cell damage breaks down the Tight Junctions (the glue holding your intestinal wall together), directly causing Leaky Gut Syndrome.

## 2. The Leaky Gut Problem: Why Standard Magnesium Fails
When MTX causes a leaky gut, standard magnesium absorption is severely disrupted in two ways:

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## Why Magnesium Bisglycinate bypasses this entire problem:
As established, Magnesium Bisglycinate bypasses the damaged TRPM6/7 ion channels by using the PepT1 protein pathway.

1. It does not wait for healthy mineral channels; it slips through as a protein.
2. It does not draw water into the colon, preventing the diarrhea that plagues MTX patients.
3. The glycine it delivers actively helps repair the tight junctions broken by MTX, helping to "heal" the leaky gut and reduce RA systemic flares. [17]

[1] [https://pmc.ncbi.nlm.nih.gov](https://pmc.ncbi....
[2] [https://pmc.ncbi.nlm.nih.gov](https://pmc.ncbi....
[3] [https://synapse.patsnap.com](https://synapse.pa...
[4] [https://chicagoarthritis.com](https://chicagoar...
[5] [https://practice365.co.uk](https://practice365....
[17] [https://creakyjoints.org](https://creakyjoints....

These Are the Methotrexate Side Effects That Make Arthritis Patients Stop Taking It

https://creakyjoints.org/acr-2019/methotrexate-side-effects-patient-perspective/

Methotrexate for Rheumatoid Arthritis: Dosage, Effects, and When to Switch to Biologics - Chicago Arthritis and Regenerative Medicine

https://chicagoarthritis.com/methotrexate-for-rheumatoid-arthritis/

What is Methotrexate used for?

https://synapse.patsnap.com/article/what-is-methotrexate-used-for

Are dietary vitamin D, omega-3 fatty acids and folate associated with treatment results in patients with early rheumatoid arthritis? Data from a Swedish population-based prospective study

https://pmc.ncbi.nlm.nih.gov/articles/PMC5541601/

Gut Microbiota–Medication Interaction in Rheumatic Diseases

https://pmc.ncbi.nlm.nih.gov/articles/PMC8678121/

PubMed Central (PMC)

https://pmc.ncbi.nlm.nih.gov

Chicago Arthritis & Regenerative Medicine - Non-Surgical Orthopedics & Rheumatology

https://chicagoarthritis.com

Synapse - Global Drug Intelligence Database

https://synapse.patsnap.com

CreakyJoints

https://creakyjoints.org