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A myRAteam Member asked a question 💭
San Francisco, CA
February 4
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Are you asking about anti-cyclic citrullinated peptides (anti-CCPs) in relation to rheumatoid arthritis?

Anti-CCPs are proteins that appear in the blood of many people with RA. They're also called anti-citrullinated protein antibodies (ACPAs). A simple blood test can detect these antibodies.

Up to 80 percent of people Show Full Answer

Are you asking about anti-cyclic citrullinated peptides (anti-CCPs) in relation to rheumatoid arthritis?

Anti-CCPs are proteins that appear in the blood of many people with RA. They're also called anti-citrullinated protein antibodies (ACPAs). A simple blood test can detect these antibodies.

Up to 80 percent of people with RA will have anti-CCP antibodies. Interestingly, these antibodies can show up in the blood five to 10 years before RA symptoms even appear.

When anti-CCP antibodies are present, it's called seropositive RA. If they're not detected, it's called seronegative RA. Having seropositive RA may mean you're more likely to develop symptoms outside the joints, like rheumatoid nodules or other complications.

The good news is that treatments for RA work for both seropositive and seronegative cases. Your rheumatologist can help determine the best treatment plan based on your specific situation.

Is there something specific about peptides and RA you'd like to know more about?

February 4

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