Does methotrexate cause hair thinning?
Hair thinning or hair loss is a known side effect that some people experience while taking methotrexate for rheumatoid arthritis. This happens because methotrexate affects rapidly dividing cells, which includes hair follicles.
If you're experiencing hair thinning while on Show Full Answer
Does methotrexate cause hair thinning?
Hair thinning or hair loss is a known side effect that some people experience while taking methotrexate for rheumatoid arthritis. This happens because methotrexate affects rapidly dividing cells, which includes hair follicles.
If you're experiencing hair thinning while on methotrexate, here are some things that may help:
- Talk to your rheumatologist about taking folic acid supplements, which can help reduce some methotrexate side effects
- Ask about adjusting your methotrexate dose if the hair loss is significant
- Be gentle with your hair - avoid harsh treatments or excessive heat styling
- Consider using mild, moisturizing hair products
It's important to discuss this side effect with your doctor rather than stopping methotrexate on your own, as stopping treatment can lead to RA flare-ups. Your healthcare team can work with you to manage this side effect while keeping your RA under control.
Many myRAteam members have shared similar experiences and found ways to manage hair changes while continuing their treatment.
December 21, 2025
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