How can you manage nausea and stomach issues during your first week on methotrexate?
Gastrointestinal problems like nausea, vomiting, and diarrhea are the most common side effects of methotrexate, affecting between 20 to 65 percent of people with RA. The good news is there are several strategies that can help.
Here are Show Full Answer
How can you manage nausea and stomach issues during your first week on methotrexate?
Gastrointestinal problems like nausea, vomiting, and diarrhea are the most common side effects of methotrexate, affecting between 20 to 65 percent of people with RA. The good news is there are several strategies that can help.
Here are some helpful approaches to try:
- Take methotrexate after a meal when your stomach is full, which can reduce nausea
- Schedule your dose on Friday or Saturday so you have the weekend to recover from side effects
- Ask your doctor about taking a folic acid supplement, which can help minimize stomach pain and other side effects
- Talk to your doctor about medications to treat nausea specifically
- Stay well-hydrated, especially important when dealing with diarrhea
Many people find these digestive issues improve over time. A myRAteam member shared that in the beginning they felt worse the day after taking methotrexate, but after about six months, they no longer had this problem.
Since you're just finishing your first week, it's important to keep your rheumatologist informed about these symptoms. They can help adjust your dose or timing, or suggest additional ways to manage these side effects while your body adjusts to the medication.
December 11, 2025
Join
Your Privacy Choices
