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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myRAteam Member asked a question 💭
Southern Oregon

I just switched from Orencia and I’m so tired. The inflammation isn’t coming down yet and it’s been 2 months 🥲

September 22, 2025
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Reactions
A myRAteam Member

Hi Cassia,
I was on Simponi injections and it worked for a year and then it just stopped....grr!
Anyway, it takes about 3 to 6 months for new meds to improve things, so hang in there.
I hope you feel better soon.

October 11, 2025
myRAteam

While Simponi Aria isn't specifically mentioned in the search results, infusion therapy with biologics can help reduce fatigue and other RA symptoms by targeting inflammation at its source. Most people start seeing improvements within 3-8 weeks after beginning infusion treatments.

Common side effects of biologic infusions Show Full Answer

While Simponi Aria isn't specifically mentioned in the search results, infusion therapy with biologics can help reduce fatigue and other RA symptoms by targeting inflammation at its source. Most people start seeing improvements within 3-8 weeks after beginning infusion treatments.

Common side effects of biologic infusions can include:
• Upper respiratory infections
• Skin infections
• Urinary tract infections
• Infusion reactions (especially after first treatment) Infusion reactions may include:
• Itching
• Swelling
• Hives
• Difficulty breathing
• Chills or fever
• Blood pressure changes

To help minimize side effects, stay well hydrated before your infusion. Wear comfortable clothing and consider bringing activities to pass the time during treatment. Your healthcare team may give you antihistamines before the infusion to help prevent reactions.

September 22, 2025

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