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There is a 8 week time frame between the last onboarding dose and the normal dose (frequency is the only difference, not dosage). Can anyone tell me how you felt before the first normal one of 8 weeks. Because I was barely moving, living, or anything the last 2 weeks before it. Is this normal? Any help would be great. Thank you.

September 18, 2025
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A myRAteam Member

I was on Sumponi Aria infusions every 8 weeks after the onboarding phase & it would wear off well before my next infusion & the frequency couldn't be adjusted so my Rheumatologist switched me to Orencia & now my infusions are every 4 weeks which has helped.

September 20, 2025
myRAteam

What you're experiencing with Remicade (infliximab) is something many myRAteam members have shared about. The initial treatment schedule involves doses every 15 days, then transitions to maintenance doses every 8 weeks. It's common to feel the medication's effects wearing off before the next scheduled dose during this Show Full Answer

What you're experiencing with Remicade (infliximab) is something many myRAteam members have shared about. The initial treatment schedule involves doses every 15 days, then transitions to maintenance doses every 8 weeks. It's common to feel the medication's effects wearing off before the next scheduled dose during this transition period. Your experience of having difficulty moving and functioning in the last couple weeks before your next dose is a pattern some people notice. This may indicate that you and your healthcare provider need to discuss:

• Adjusting your dosing schedule
• Combining Remicade with methotrexate (which is often done)
• Monitoring how long the medication remains effective for you personally

Remember to track your symptoms and share these experiences with your healthcare provider, as they can adjust your treatment plan accordingly.

September 18, 2025

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