Common side effects of RA medications like methotrexate include:
• Gastrointestinal issues (nausea, vomiting, diarrhea) - affecting 20-65% of people
• Mouth and throat sores
• Fatigue and "mental fog" (especially the day after dosing)
• Headaches
• Hair loss (less common) For biologic and targeted DMARDs, common side Show Full Answer
Common side effects of RA medications like methotrexate include:
• Gastrointestinal issues (nausea, vomiting, diarrhea) - affecting 20-65% of people
• Mouth and throat sores
• Fatigue and "mental fog" (especially the day after dosing)
• Headaches
• Hair loss (less common) For biologic and targeted DMARDs, common side effects include:
• Upper respiratory infections
• Headaches
• Gastrointestinal issues
It's important to note that when new RA medications first come out, side effects may seem more severe because they're initially prescribed to people with more difficult cases. As medications become more widely used, reported side effects often become less frequent.
September 13, 2025