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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
September 6, 2025
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There are several effective ways to manage mouth sores from methotrexate. The most important first step is to talk with your rheumatologist, who may recommend:

• Adjusting your methotrexate dosage
• Switching to injectable methotrexate instead of oral
• Splitting your dose into two daily doses
• Increasing your folic acid Show Full Answer

There are several effective ways to manage mouth sores from methotrexate. The most important first step is to talk with your rheumatologist, who may recommend:

• Adjusting your methotrexate dosage
• Switching to injectable methotrexate instead of oral
• Splitting your dose into two daily doses
• Increasing your folic acid supplementation, which has been shown to significantly reduce mouth sores While waiting for the sores to heal, these methods can help reduce discomfort:

• Using saltwater rinses
• Using alcohol-free mouth rinses
• Asking your doctor about prescription "magic mouthwash" with lidocaine
• Sucking on mints or hard candies

Remember to always consult with your doctor before making any changes to your medication routine or trying new treatments.

September 6, 2025

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