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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
August 5, 2025
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Yes, inflammation and RA flares can contribute to weight loss. During periods of high disease activity, chronic inflammation can lead to metabolic hyperactivity, which may cause your body to lose weight unintentionally. This can happen even if you're not trying to lose weight.

A specific condition called rheumatoid Show Full Answer

Yes, inflammation and RA flares can contribute to weight loss. During periods of high disease activity, chronic inflammation can lead to metabolic hyperactivity, which may cause your body to lose weight unintentionally. This can happen even if you're not trying to lose weight.

A specific condition called rheumatoid cachexia can develop, which may cause:
• Muscle wasting
• Overall weakness
• Unintended weight loss If you're experiencing unexplained weight loss during flares, it's important to discuss this with your doctor. They may recommend:
• Adjusting your medications, possibly including TNF inhibitors to control inflammation
• Creating a balanced nutrition plan
• Starting an appropriate exercise routine to maintain muscle mass
• Working with a physical therapist to develop joint-friendly strengthening exercises

August 5, 2025

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