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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
June 15, 2025
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A myRAteam Member

I've been taking both for several years with no side effects.

June 17, 2025
myRAteam

When taking hydroxychloroquine and leflunomide together, it's important to be aware that leflunomide may affect how NSAIDs (common pain medications) work in your body. Your doctor will carefully monitor this combination to ensure it's working effectively for your RA.

Some people may experience stomach upset with Show Full Answer

When taking hydroxychloroquine and leflunomide together, it's important to be aware that leflunomide may affect how NSAIDs (common pain medications) work in your body. Your doctor will carefully monitor this combination to ensure it's working effectively for your RA.

Some people may experience stomach upset with hydroxychloroquine, which can vary depending on whether you're taking brand-name Plaquenil or generic hydroxychloroquine. Be sure to tell your doctor if you notice any new or different side effects. Remember to take your medications exactly as prescribed and don't adjust dosages on your own. If you experience any issues getting your prescriptions filled or have concerns about side effects, reach out to your rheumatologist right away. They can help ensure you're getting the most benefit from your treatment combination.

June 15, 2025

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