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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Does anyone take Leuflominide along with Hydroxychloroquine as their RA medicine regimen. If yes, what has been your experience with them?

A myRAteam Member asked a question 💭
Shallotte, NC
June 7, 2025
 · 
Reactions
A myRAteam Member

Interesting bc my Dr mentioned this med. In all honesty not sure about bc I don't do good with meds

June 7, 2025
A myRAteam Member

Good morning ☀️ I tried replacing mtx with leflunomide for a short time. Its side effects, upset stomach and severe diarrhea. Went back to mtx. I also take a weekly enbrel injection. Let us know if that combo helps you. Hope today brings you some sunshine and laughter 🤗

June 7, 2025
myRAteam

Yes, leflunomide (Arava) and hydroxychloroquine (Plaquenil) can be used together as part of a combination therapy approach for treating rheumatoid arthritis. This type of combination is considered a "double therapy" with two different types of disease-modifying antirheumatic drugs (DMARDs). Before starting or adjusting any Show Full Answer

Yes, leflunomide (Arava) and hydroxychloroquine (Plaquenil) can be used together as part of a combination therapy approach for treating rheumatoid arthritis. This type of combination is considered a "double therapy" with two different types of disease-modifying antirheumatic drugs (DMARDs). Before starting or adjusting any medication combination, it's important to discuss potential interactions with your healthcare provider. They can help:
- Monitor for side effects
- Adjust doses if needed
- Change medication schedules
- Evaluate if the combination is working effectively for you

Remember to keep track of any symptoms or side effects you experience so you can accurately share these details with your doctor during appointments.

June 7, 2025
A myRAteam Member

I have read it's a good one, but actually haven't spoken with anyone using this combo. I was MTX and got off it a year ago

June 15, 2025
A myRAteam Member

Leuflomide - I had every side effect and stopped after 2 weeks. Sent from my iPhone

June 7, 2025

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