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A myRAteam Member asked a question 💭

I have seronegative RA and burning hands and feet. Docs say it’s small fiber neuropathy but say it’s not related to my RA because I’m seronegative.

April 4, 2025
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A myRAteam Member

Thank you! So kind of you to respond! I have constant burning without hives. I’ll ask my rheumatologist when I see her if it could be what you suggest. Thank you! The neurologists say it’s small fiber neuropathy and that it must be from my RA but my Rheumatologist says because my RA is seronegative, the neuropathy isn’t from my RA. I just wish I had an answer as to why I have the small fiber neuropathy. Neurologists (I’ve seen 3) just don’t have interest in answering why. I have just read that some medications for RA- plaquenil and sulfasalazine can cause the burning. I’m on both medications but no doctor has ever mentioned this. For me, It feels like pain would be easier to tolerate if there was a reason why. Thank you again for responding! So very kind of you.
Amy

April 4, 2025
A myRAteam Member

You might have a type of urticaria (fancy name for hives). I get it occasionally when my hands/feet undergo a rapid temperature change. My son gets it from vibration. A friend gets it from cold.

April 4, 2025
myRAteam

Seronegative RA can affect multiple joints, including those in the hands and feet, causing symptoms like pain, swelling, and tenderness. The condition can present with various symptoms, and while seronegative RA means you don't have certain antibodies in your blood, it doesn't mean your symptoms are any less real or severe Show Full Answer

Seronegative RA can affect multiple joints, including those in the hands and feet, causing symptoms like pain, swelling, and tenderness. The condition can present with various symptoms, and while seronegative RA means you don't have certain antibodies in your blood, it doesn't mean your symptoms are any less real or severe than those with seropositive RA. It's important to note that seronegative RA can be more challenging to diagnose, and symptoms may sometimes be misattributed to other conditions. A myRAteam member shared a similar experience, reporting that despite having documented RA symptoms and high inflammation markers, they initially faced challenges getting proper diagnosis due to negative blood tests. Consider seeking a second opinion from a rheumatologist who has experience treating seronegative RA if you're concerned about your symptoms.

April 4, 2025

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A myRAteam Member asked a question 💭
Syracuse, NY

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