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Just had blood test and have been told that nothing is showing, even though my joints feel red hot , i.e hip knee and thumb . I was thinking of stopping the Methotrexate.Has anyone got any advice ref this

March 23, 2025
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A myRAteam Member

I have seronegative RA which means that NOTHING shows up on my blood tests. Ask your Rheumatologist if you might have seronegative RA.

March 25, 2025
A myRAteam Member

I'm in the same boat I'm seronegative!

March 23, 2025
A myRAteam Member

I am RA seronegative, with sjogens, fibromyalgia, osteoporosis and Osteoarthritis. I originally had an extremely high ANA test but the rest was normal. Since I have had some other high numbers but not RA. My rheumatologist said if it quacks like a duck and looks like a duck, it's a duck! Lol...I like that analogy.

March 23, 2025
myRAteam

It's important not to stop taking methotrexate without discussing it with your doctor first. Even if blood tests aren't showing inflammation, your symptoms are real and valid. Stopping methotrexate suddenly can increase your risk of RA flares, which could make your symptoms worse.

If you're feeling good, that likely means Show Full Answer

It's important not to stop taking methotrexate without discussing it with your doctor first. Even if blood tests aren't showing inflammation, your symptoms are real and valid. Stopping methotrexate suddenly can increase your risk of RA flares, which could make your symptoms worse.

If you're feeling good, that likely means the medication is working effectively. Stopping it could cause your condition to worsen, even if current tests aren't showing inflammation. Instead of stopping methotrexate, talk to your rheumatologist about your concerns. They can help evaluate your symptoms and possibly adjust your treatment plan. They might suggest ways to manage side effects, like taking methotrexate after meals or adjusting your dosing schedule. They can also recommend additional therapies to help manage your current joint symptoms.

March 23, 2025
A myRAteam Member

So true!

March 23, 2025

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