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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

. I am on a biologic Rinvog and my RA doctor just added leflunomide a Dmard go my regimen. Has anyone used both together?

A myRAteam Member asked a question 💭
Palm Harbor, FL
May 18, 2024
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myRAteam

Yes, combining a biologic DMARD like Rinvoq (Upadacitinib) with a conventional DMARD such as Leflunomide is a common strategy to manage rheumatoid arthritis (RA) more effectively. This approach can help in controlling symptoms and slowing disease progression by targeting different aspects of the immune system. However, it's Show Full Answer

Yes, combining a biologic DMARD like Rinvoq (Upadacitinib) with a conventional DMARD such as Leflunomide is a common strategy to manage rheumatoid arthritis (RA) more effectively. This approach can help in controlling symptoms and slowing disease progression by targeting different aspects of the immune system. However, it's important to monitor for any potential side effects and interactions. Always discuss any concerns or unusual symptoms with your RA doctor to ensure the best care tailored to your condition.

May 18, 2024
A myRAteam Member

Ny apologies, in my original question I referred to Rinvoq as a biologic but it is actually a Dmard Jak Inhibitor and I just learned that on here thank you!

May 19, 2024
A myRAteam Member

Hi Zen, I take mtx pills & a weekly enbrel injection . I went off mtx for a few weeks, replaced with leflunomide. The leflunomide didn’t agree with me. Very nauseous and terrible diarrhea. I’m back to my original mtx & enbrel. Hope you & your dr find what works best for you 🤗

May 19, 2024
A myRAteam Member

Hi Zen, I had been on mtx for about two years when I started getting nodules. I thought maybe mtx was the cause.🤔 I asked my doctor to switch to leflunomide. When I had those side effects we switched back. I haven’t had any further nodule issues 🤪

May 20, 2024
A myRAteam Member

Thanks Veronica. Why did you stop the mtx?

May 19, 2024

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