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Yes, many women with rheumatoid arthritis (RA) report experiencing more pain during their menstrual cycle. It's noted that fluctuations in estrogen and progesterone, the primary female reproductive hormones, can influence the immune system as well as pain perception. Women often experience more pain when the levels of these Show Full Answer

Yes, many women with rheumatoid arthritis (RA) report experiencing more pain during their menstrual cycle. It's noted that fluctuations in estrogen and progesterone, the primary female reproductive hormones, can influence the immune system as well as pain perception. Women often experience more pain when the levels of these hormones are low, which is typically the case during menstruation. This hormonal fluctuation explains why women are more likely to experience RA flares during their menstrual cycle.

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