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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
March 9, 2023
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Members shared their experiences transitioning to Humira after hydroxychloroquine and methotrexate stopped working, with many reporting that... Read more

Members shared their experiences transitioning to Humira after hydroxychloroquine and methotrexate stopped working, with many reporting that Humira helped manage their rheumatoid arthritis symptoms, though most emphasized it took several months to fully take effect. Several members noted that combining methotrexate with Humira produced the best results for symptom control, while others shared that individual biologics tend to lose effectiveness after a year or two, requiring switches to alternatives like Rituxan, Rinvoq, or Enbrel. A recurring theme was that finding the right medication involves trial and patience, with members offering encouragement and reminding the original poster that every body responds differently to treatment.

A myRAteam Member

I was on Hydroxychloroquine and methotrexate together. When that no longer worked I was put on Humira every 2 weeks then weekly. It worked well for me for several years. I have since gone onto Rituxan.
Good luck!

May 9, 2023
A myRAteam Member

That is the same path I took. Hydroxychloroquine, then methotrexate (I love methotrexate, no so side effects except for weight loss that I needed.)

I've been on Humira about 15 months. I don't feel as good and flare more than I did on methotrexate, but it does work.

I notice when I have to skip a dose for vaccinations.

Also, it took several months to kick in.

I'm hoping and praying it helps you quickly.

March 10, 2023 (edited)
A myRAteam Member

Thank you so much for the info

March 10, 2023
A myRAteam Member

It’s always a try it and see situation. I took Enbrel among other things and that helped a while but I have very little body fat and it was very painful to me. I was started on Riutuxin and it was great. I loved it and it helped so much. So you just have try them to see what works the best for you!! 😃😃

July 4, 2023
A myRAteam Member

Humira worked well for me for about a year and a half then to Rinvoq. Imbrel before humira. But all of them never have lasted more than 2 years. Best wishes.

July 3, 2023

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