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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Methotrexate

A myRAteam Member asked a question 💭
Worcester, MA

Will you please share your experience with methotrexate( good, bad or otherwise) with me? Thanks

March 17, 2022
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Answer Summary

Members shared mixed experiences with methotrexate for rheumatoid arthritis, with some reporting minimal side effects but limited pain relief,... Read more

Members shared mixed experiences with methotrexate for rheumatoid arthritis, with some reporting minimal side effects but limited pain relief, while others described severe reactions including frequent infections, nausea, and increased pain that led to discontinuation. Several members found that methotrexate worked better when combined with biologics like Enbrel, Humira, or Cosentyx, with these combination therapies providing more significant inflammation control than methotrexate alone. A recurring theme was the highly individual nature of the medication's effectiveness, the need for patience during dosage adjustments, and the importance of open communication with rheumatologists to find the right treatment plan when methotrexate falls short.

A myRAteam Member

Hello there. I've been on methotrexate since June. On the plus side, I haven't experienced side effects but on the downside, it didn't help at all. My rheumatologist added humira injections to the mix about 5 months ago and that has made quite a difference. Again, I haven't noticed any side effects, so I'm very grateful for that.

March 17, 2022
A myRAteam Member

I have been on it for about 13 years. I have no side effects except heartburn. It does help but for me it’s not enough by itself. I take a biological alongside it.

March 18, 2022
A myRAteam Member

My mother was given the methotrexate and it made her very sick and made her pain worse. They haven’t as of yet tried that one with me and I am not sure that I want them to after going through it with Mom.

March 17, 2022
A myRAteam Member

I've been on it for about 5 months now. I don't think it's working for me. Last dr visit my blood work showed progression so dr upped dosage from 4 pills 1x week to 6 pills 1x week. She said if next visit still shows progression she wants to add enbrel shot 1x week. I'm willing to try it

March 17, 2022
A myRAteam Member

Thanks for sharing. All considerations and explained to me as well by my MD.
Stay well. Thanks again.

March 19, 2022
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