I had a bad reaction to Sulfasalazine (and other DMARDs). After three weeks, I developed large rashes. During the weeks leading up to the reaction, I started feeling very off and irritable. I felt 10x better once I stopped taking it.

I'm on Sulfasalazine as well, to start with I had really bad headaches and nausea, it does suppress appetite though havent loss much weight on it.
I don't feel its worked for me as I seem to be in a loop of constant flares, so will be asking to try something else.
Good luck

I took sulfasalazine for a few months. I did not find it helped me at all and it made me have no appetite/no food sounded good to eat. I only could take 3 500 mg pills per day before it caused nausea. I stopped it because of these side effects, which all went away after I stopped it thankfully! I hope it works better for you!

I was taking it but even on a low dose I would get so tired that I finally had to stop taking it. I don’t know if anyone else had this problem.

Yes, I took sulfasalazine for 3 months and felt it was helping with RA symptoms. I had no ill side effects as in nausea, headache etc. Unfortunately, it then showed up in liver during monthly blood work, so had to be discontinued. On we went to leflunomide which after 4 months did nothing for RA symptoms. I am now on a biologic, rinvoq, and crossing my fingers. Hope this helps.