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The methetrexate made me so exhausted last weekend, I was hoping that take it Friday night and sleep most of it. Didn't know if taking the medication 12 or so hours earlier was a problem. Thank you for any help. Krista

November 10, 2021
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A myRAteam Member

Thank you!

November 10, 2021
A myRAteam Member

I would ask your rheumatologist? I feel whatever works for you. Only thing might be to take with food as it can upset the stomach. You could ask your pharmacist too. I take my meds in the evening on Fridays so if I feel tired or anything I have the weekend. I took methotrexate back in 2017. I tried pill version but it did not help. Then injections but had to stop after my doctor raised my dose due to stomach issues.

November 10, 2021

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