I have taken all of these but I never ended up with the shingles. I took each one for so long they just stopped working on me.

I am on Simponi and have been for 2 years. No real side effects and it has been working great for me. I take it alongside methotrexate.

I have a self injectable Eppi pen which I inject every 4 weeks. Sometimes it seems to stop working by week 3 but once I get my next dose I’m usually ok in a couple of days.

Simponi is a very expensive drug so we are required to have a blood test before each new prescription to prove that it is actually working. If a blood test shows lots of inflammation and not much benefit then funding will be withdrawn for that drug. That’s how it works in Australia anyway. Other countries may have different rules though.

One word of caution though, after my first couple of injections I developed shingles. Apparently this is a known thing (although I didn’t know it at the time)
I believe there is a shingles vaccine that you can have prior to starting Simponi. I would mention this to your doctor because I can tell you from experience, shingles is not fun.

Good luck, I hope it works for you. I am happy to keep taking it for as long as I can. It’s the most effective drug I have tried so far.

Best wishes Cherry 🍒

All the biologic drugs potentially have scary side effects, but mostly they don't happen (I have tried 6), and some of the drugs work well, and it beats the heck out of RA's miserable pain and disability.

I have have taken all three. They worked for a while then had to change bc of side affects or they would stop working on me.

I have been in every biologic & Simponi was one of them. I did not have side effects but did not work for me. I am back on Enbrel because I have to be on something. RA is a drag!!!