Answer Summary

Members shared mixed experiences with methotrexate and rheumatoid nodules, with several describing nodules that shrank or disappeared after... Read more

Members shared mixed experiences with methotrexate and rheumatoid nodules, with several describing nodules that shrank or disappeared after stopping the medication, while one member noted their nodules nearly vanished after switching from Enbrel to Xeljanz while continuing methotrexate. Some members reported that their doctors acknowledged methotrexate can cause or worsen nodules, leading to multiple surgeries in one case, though others were told nodules are simply part of rheumatoid arthritis itself and may appear after flare-ups. A recurring theme was frustration with conflicting medical advice and the search for alternative treatments that balance disease control with side effects like nodules, chronic cough, and other symptoms.