I have been on Simponi Aria for years now and love it....I am in chemical remission with my RA. I take the Simponi every 8 weeks and methotrexate every week. I get my infusions on a Friday so I can go home and go to sleep. You will most likely pre treat with Tylenol and Benadryl. The Benadryl knocks me out! If I have to drive or run errands after the infusion I take an Allegra instead of the Benadryl. I don't think you will have side effects much from the infusion, just the pretreating allergy pills. But I just realized you posted last year...I hope you got your answer and are able to have your infusions!