Yes Brenda you have it, the pain never goes away. I can't bare weight on my right leg My knee is bad but these lumps are like my calf is Charlie horsing all the time, since I noticed it I do wake up with Charlie horses in the right leg, from a dead sleep to screaming and my leg is up in the air. My husband now knows to pull my toes forward to relieve the muscle. I was on Methaltrexate for a very short period when I was first diagnosed over 6 years ago, but lumps just developed summer of 2016 when I noticed my feet and hands hurt so bad I could not walk or use my hands they swell so bad, that's when they started looking at Rheumatoid Factors. I have suffered with PSA for over 10 years undiagnosed for years is now systemic (in eyes and watch heart), as I have a high tolerance to pain, but when I could not get out my car but walked and pain went away I started seeing a slew of doctors. I spiraled down from there until Enbrel for a couple years I was rockin had my energy back worked out at 4 am, worked stressful position 60 plus hours a week no sweat. but that changed. Now one day at a time. I'm grateful my kids are grown I can barely take care of our dog. Work is getting too hard but too young to quit yet. So I keep hope a live. Thank you so very much for listening to me, I really thought I was going crazy, doctor saying it is a cyst therapist says it is a knot in the muscle pain doc says knot in muscle, but it never goes away now I have 2. No more massages on them. LOL Oh I can't tell you how much better I feel.

YES!! I thought it was just me! Mine started shortly after I began Methytrexate and it feels like I have a cramp in my left calf. Was starting o wonder if I have a blood clot!

It's kind of hard to depend on time between flares when you fel like you are in a flare most of the time.

I have nodules on my elbows and one leg but if I had knots I'd see my doctor. There is many things that it could be. My mother had melanoma which started on the back of her leg. I don't want to scare you but I believe you should seek medical attention. I've had RA for a long time and I've never had knots. I also have Psoriatic Arthritis and the nodules come from that. But I went to my family doctor then to a Dermatologist
before showing them to my Rheumatologist. Never to early to be sure!

I've had them my rem doc suggested for me not to touch them it makes them worst and tbat they come along with flare ups but go away soon as flare up does i get them on tbe knees mostly ..very painful indeed.