Hi Lori!,,I just took my 8th dose this w/e and its the first time I have felt really good since starting it! I was beginning to have doubts,,but oh my these past two days have been a God send to me!,,So hang in there girl!,Give it some time,,and hope you you get some great results!,,Huggs to you and hpe your having a good day!

my dr told me full affects, 6 weeks

Yes, hang in there! It took three months before I felt any improvement. Had to supplement with malaria med, prednisone and Vimovo anti flam. After 3 months, it started to work Today I only take Tramezac once a day and Vimovo occasionally but still the methotrexate. It does work for me but it has side affects i.e. hair very brittle and breaking and falling out and nails a mess! It is worth being patient though!

Hi I have taking methotrexate for about 4 months it helped a little bit very few side affects know doctor told me to also take plaquenil taking both medications I am starting to feel relief I have taking plaquenil for 6 weeks. Rob

My doc said you have to be on it for at least 4 weeks to notice any improvement