Are there others out there that are seronegative? How aggressive has your doctor been with your treatment? Any MRIs, etc?
I am seronegative also. I started having pains in my hands and feet in 2003 or 2004. My hands would turn a peachy color, and holding a piece of paper between my fingers hurt. My doctor started me on mobic. I took other nsaids. She had told me i was a puzzle because all my test were pretty much negative. First hand xrays according to radiologist showed some early signs of rhematoid disease. I had read some books on RA and one said talked about seronegative RA, which i thought i had. Then i read another book that said there was no such thing. Then my first RA doctor retired, and i got a new doctor. She is the one who told me i had RA and she had run the vectra test. Then i started taking hydroxycloriquine, tramadol, then arava, and now i started xljanz 3 weeks ago. In one book i read it reccomended that even seronegative patients be treated aggressively, to get it undercontrol early and to lesson joint damage.
I'm also seronegative. But no MRI's. Just exrays. I'm on a biologic and it has helped when not much else has. But I also have osteoarthritis. I am rarely without a symptom. Fatigue seems to be my #1 symptom that does not respond to any medicine. It took my doctor over a year to find a medicine that worked for me.
I have been Sero negative RA for 23years I also have oesteoarthritis. I have always been treated aggressively by my Consultant, Plaquenil, sulphasalazine, Methotrexate, Methotrexate and Enbrel then Metho and Roactemra now just Roactemra occ predisolone when flair ups my inflammatory markers are normal at present.
I believe because I was treated the rate of my decline and the damage to my joints has been minimalised although I am now noticing more damage, although much less than some other people I know who haven't been treated as aggressive ly.
I am also seronegative, I continuously pushed to be conservative with treatment, because I was afraid of long term problems- I was diagnosed at 27. For the last two years I have treated with prednisone and meloxicam. In October I finally talked to my rheumatologist about issues I was having getting back to full time work after being on disability for kidney stones/septic shock/ kidney failure and rhabdomyolysis this summer. He suggested I try Plaquenil--- and at the same time (before starting) he ordered the Vectra DA test. In February, he went over my high Vectra DA results and had a long conversation with me about the Need for more aggressive treatment. He said he would test again in June. I'm on the fence. My Rhumetologist is absolutely amazing, I believe and trust what he is recommending for me, but I think I'm in denial... I didn't anticipate my score being so high-- even though I haven't felt my best.