I have been on it for 12 years and it has helped. After several months, my rheumy added remicade an the combo was like a magic elixir.

I was on the mtx pills and when they were causing issues dr switched me to the injections. Wish it had worked but those were the most miserable months since I was diagnosed. Now I'm on Leflunomide and what a difference. One pill a day with my B12, omega 3 and Tumeric and I am good to go for the whole day

Your symptoms sound rather like mine. I'm also seek negative with AS symptoms and all joints affected. I can't take Methotrexate orally, so I inject myself weekly along with Orencia. A few years down the track and I'm doing pretty well.

I started on Methotrexate (8 pills) and it got me walking again, but made me nauseous. I lowered my dose to 6 and did better, but then my liver enzymes went up and the Rheumy lowered it to 4. That seems to be working for me. I also take Humira shots though and that has really helped.

I have been on methotrexate for about a year. I am doing very well on it. My only complaint has been Hair loss. I am 70 yrs.old but had a thick head of hair when I started and now it has thinned a lot.