I keep hearing people talk about how intolerable @methotrexate is. I am curious to hear from people who find it to be helping. I started it 3 weeks ago and I can't believe how amazing I feel. Its like someone oiled my joints and told my muscles to behave! I wonder if it's something specific to my condition. I'm sero negative poly inflammatory arthritis. Essentially that just means I have Ankylosing spondylitis symptoms and RA. Virtually every joint is involved with any number and combination… read more
I have been on it for 12 years and it has helped. After several months, my rheumy added remicade an the combo was like a magic elixir.
I was on the mtx pills and when they were causing issues dr switched me to the injections. Wish it had worked but those were the most miserable months since I was diagnosed. Now I'm on Leflunomide and what a difference. One pill a day with my B12, omega 3 and Tumeric and I am good to go for the whole day
Your symptoms sound rather like mine. I'm also seek negative with AS symptoms and all joints affected. I can't take Methotrexate orally, so I inject myself weekly along with Orencia. A few years down the track and I'm doing pretty well.
I started on Methotrexate (8 pills) and it got me walking again, but made me nauseous. I lowered my dose to 6 and did better, but then my liver enzymes went up and the Rheumy lowered it to 4. That seems to be working for me. I also take Humira shots though and that has really helped.