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Sero-negative RA

A myRAteam Member asked a question 💭
Carroll, IA

For those of you with seronegative RA, what is you C reactive and SED rate? Mine are elevated, but not off the charts like a lot of you. What medicine did they start you on first?

June 17, 2016
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Answer Summary

Members with seronegative RA shared their varied inflammatory marker levels, with some experiencing consistently elevated CRP and ESR while... Read more

Members with seronegative RA shared their varied inflammatory marker levels, with some experiencing consistently elevated CRP and ESR while others had readings that appeared normal on standard tests until a Vectra blood test revealed inflammation. Several members described their medication journeys, starting with combinations like methotrexate, prednisone, and Plaquenil, then progressing through biologics such as Humira and Xeljanz when initial treatments stopped working effectively. A recurring theme was the challenge of managing unpredictable symptoms, particularly joint stiffness and overwhelming fatigue, while weighing medication side effects like vision concerns with Plaquenil and anxiety or hunger with steroids against the need to slow disease progression.

A myRAteam Member

Hi Patty!! I am happy to also be in touch with someone that is experiencing a similar journey to me. For the moment my GP is happy for me to take the Celebrex while I wait to go back to the Rheumatologist, we have discussed though that the time may be coming for the DMARDS. Like I said before my joints are not too bad, I have the nighttime and morning stiffness and so far it's only my elbows and left wrist that have swelling. I also have eye problems, dry and irritable and if I am very fatigued my eyes usually my left one are usually at their worse!!

June 25, 2016
A myRAteam Member

I have been diagnosed too with Seronegative Arthritis around 7 months ago just had bloods and my CRP was 13 and ESR 35. My levels are slowly rising every 3 months, I am on Celebrex when required and also take some natural remedies eg: turmeric, fish oil and magnesium.
I am slowly having more bad days, I can handle the joint stiffness at the moment but not the fatigue!!

June 23, 2016
A myRAteam Member

Holy Cow! @A myRAteam Member!!
Seronegative RA is when you have all the clinical findings of RA, but do not test positive for the Rhuemathoid factor. Sometimes C-Reactive and SED rate will be elevated, but not always. I had been on high dose NSAIDs for over a year, then a course of prednisone when I had blood work done by Rhuemy. So SED rate was slightly elevated. Went off everything for a couple days and SED rate was rising. So she knows there is inflammation there, just knows it's being masked. Seronegative RA is usually a milder form. But can turn to seropositive RA down the road.

June 18, 2016
A myRAteam Member

Blood work. it measures inflamation markers. 1-29 is low,above 30 moderate etc up to 100

June 17, 2016
A myRAteam Member

I am also seronegative and my ESR is not usually "high". My doctor started me on Plaquenil and eventually methotrexate. I have tried several meds over the years and have finally landed on Humira and it works well.

March 17, 2017

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