The methotrexate will affect any cell producing organs ,but in your case it does seem that your kidneys were badly affected. They will regenerate but I agree that a cleanse is a good option

I was on methotrexate and it sent me to th ER with Anaphylaxis. So not surprised.

I"ve taken methotrexate off and on several different times, and never had this happen....... but that IS why they do blood work!

I take Milk Thistle which is a supplement you get at the nutritional stores or GNC or health food stores. It's supposed to help protect your liver. As for the renal insufficiency, I did like Rebecca, quit the soda, tea, beer and upped the water. I haven't really had any problems since. It's part of taking care of ourselves. I will cheat and have a small soda with extra ice or a coke-flavored icee when I really want the flavor. But for the most part I'm a water girl. It has helped my renal function. I went from a GFR (Glomular Filtration Rate) over 60 to a 38 then back up to over 60. So it can improve.

This happened to me 2 years ago, I stopped all meds for several months, drank more water, less caffeine, no soda, beer etc, absolutely no ibuprophen. after a few months my counts went back to normal, and I refuse to take MTX ever again. Sadly these RA meds that keep us functioning are also dangerous to our health, so I try to be very careful of everything else I put into my body. I hope you do well.