I have found that my inflammation gets better before the fatigue and pain. Maybe you will feel better soon. I hope so.

Sometimes it takes six months or more for you to REALLY feel a difference, when you start a biologic. It's been about five months based on what you have said. Give it a little more time. Praying you find relief soon. xx

How much methetrexate do you take? Or are the 6 tablets for an assortment of medications?

I haven't noticed any side effects from the Humira, and it works well for me. As for the mtx, I would love to go off it but my rheumy says it makes the Humira work better. One thing that helps me with the mtx side effects is to take the first 6 pills, in 2 pill incrimants, over several hours on a Friday night, so I sleep most of it off, and the last 2 very early Saturday morning and go back to sleep. If I start feeling fatigued later in the day I don't fight it, I lay down for a nap and I feel better afterward. As far as relieving your symptoms it seems like you need to try something other than Humira. There's lots of stuff out there now, ask your rheumy.

It's all trial and error with all the new meds out there now. I was on a enbrel & methdrexate predisone Naproxin quite a few years then Switch Humira but stopped methedraxate tried other side effects inflammation was getting better hands or feet etc so no trying Actemra infusion montly hoping it helps 2nd month.I know it's so hard with all side effects I have hair loss fatigue etc not fun sorry.Good luck to you.