Yes unfortunately it takes awhile for the meds to kick in. Autoimmune diseases are horrible. My blood markers look good a lot of the time however if you have a good doctors he/she will know that it can be a false positive /negative. When they look and feel the joints that is the true test. I have seronegative RA. My grandmother had RA. My mother had RA. My father had ALS. Hope you feel better soon.

I've been told a minimum 6 weeks but that docs usually like to reassess meds 3 months after a med change.

RA and fibro are both autoimmune , you can be seronegative and stil have RA, my rheumy told me it takes 3-6 months to see the full effect of methotrexate (6 months for full effect) such a bummer these meds take so long to work. Praying you feel better

Freeman, It can take up to 6 months for new meds to start working. If it's not working for you you should go back to your Dr. There are so so many medication for RA, they can change or add. It is just a matter of finding the right medication for you. Good Luck.
Bless you and yours

I am RF negative (seronegative) as well. Was told it was fibro for years then Rheu says seronegative RA. He told me if anything the fibro was secondary. I find it hard to be told one thing for years then another thing and how to discern them. I have also been asking myself why do I need to discern them? I guess because I need to put things into their "box" to label them. This is very frustrating with not always an answer. I take MTX and I truly don't know if it's working- but he keeps me on it. You may need to add a drug. I was on sulfasalazine but then he stopped that and added plaquenil. Talk with your doctor because it seems like it's a lot of mixing to see what helps you. Good luck and best wishes.