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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Folic Acid - Methotrexate

A myRAteam Member asked a question 💭
Mays Landing, NJ

I seem to have difficulty tolerating Folic Acid which was prescribed to help with the side effects of my injectable methotrexate. It seems that after I take it, my digestion is terrible. I'm starting to wonder if it's worth taking as my body seems to finally be adapting to the methotrexate. I've read there are natural sources of folate such as dark, leafy greens, avocado and a host of veggies. Is there a way to substitute? Has anyone else dealt with stomach woes over Folic Acid? Many… read more

August 9, 2015 (edited)
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A myRAteam Member

Mine was definitely methotrexate. Once my folic acid was increased, a lot of side effects diminished or disappeared...

August 12, 2015
A myRAteam Member

I wonder if it's the MTX and not the folic acid? I have all kind of GI issues, and folic acid doesn't bother me at all. I take 4 mg. a day, just a FYI.

August 10, 2015
A myRAteam Member

Yes I used to have problems associated with that. Then I just started putting fiber in my drinks 4 times a day and it took about two weeks but things calmed down.

August 10, 2015
A myRAteam Member

I eat half of my dinner then take the folic acid,finish dinner and don't seem to have problems. I find that if I do that with the methotrexate also I don't get sick at all.

August 9, 2015
A myRAteam Member

I take folic acid and leucovorin with the 7 pills of methotrexate. The leucovorin made all the difference.

April 19, 2021

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