Sounds like it's useless to try according to these 2 responses.

Tried it years ago when it first became popular but didn't have any response to it.

I know this is an older post but I'm on MSM with calcium, glucosamine, and magnesium and it does help me.

I used it for several years. It seemed to make a slight difference, especially at night. Now that my RA and Fibromyalgia are both really active, it does not.
Several of my doctors said it really should be taken with calcium and glucosamine chondrites to be max effective.
I'm allergic to shrimp so I can't do the glucosamine chondrites, but I did take it at night with the calcium.
Biggest problem with supplements is that they aren't regulated like big pharma drugs are, so you might not actually be getting what you think you are.