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Trexall, also known as Methotrexate (drug name) and Rheumatrex (alternative brand name), is a prescription medication approved by the Food and Drug Administration (FDA) in 1988 for treatment of rheumatoid arthritis. Trexall can reduce joint pain and swelling as well as allow for the reduction in dosage of other drugs such as Prednisone.

Trexall is an immunomodulator, or in other words, a drug that modulates the immune system. Trexall is also referred to as a disease-modifying antirheumatic drug (DMARD) or a slow-acting antirheumatic drug (SAARD). It is an antimetabolite which blocks the synthesis of purine, a protein the body needs in order to produce lymphocytes. Lymphocytes are a type of white blood cell active in the immune system. Trexall is believed to work by interfering with lymphocytes and preventing them from attacking the joints.

How do I take it?
Trexall is taken once a week, either by injection, or orally as a tablet.

Side effects
Side effects from Trexall may be worse among older adults and in those who receive higher doses of the drug.

The most commonly reported side effects of Trexall are mouth ulcers, malaise, fatigue, nausea, abdominal distress, changes in blood cell count, dizziness, abnormal liver function test results, and lowered resistance to infection.

For answers to frequently asked questions about exposure to Methotrexate during pregnancy and breastfeeding, visit the experts at

Trexall (Methotrexate) for Rheumatoid Arthritis Questions

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