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Depen is a prescription medication approved by the Food and Drug Administration (FDA) for the treatment of severe, active rheumatoid arthritis in people who have not responded to conventional treatment. Depen may be referred to by its drug name, Penicillamine. Penicillamine is also sold under the brand name Cuprimine.

In cases of rheumatoid arthritis, Depen is used as a disease-modifying anti-rheumatic drug (DMARD). Depen is believed to work by inhibiting several processes that contribute to autoimmune attacks.

How do I take it?
Depen is taken orally once a day.

Depen is available as a tablet.

Side effects
The FDA-approved label for Depen lists common side effects including changes to the sense of taste, mouth ulcers, nausea, diarrhea, vomiting, stomach pain, and loss of appetite.

Rare but serious side effects listed for Depen can include drug fever, rash, and potentially fatal conditions such as blood disorders, myasthenia gravis, and Goodpasture’s syndrome.

Depen (Penicillamine) for Rheumatoid Arthritis Questions

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