Overview
Cuprimine is a prescription medication approved by the Food and Drug Administration (FDA) for the treatment of severe, active rheumatoid arthritis in people who have not responded to conventional treatment. Cuprimine may be referred to by its drug name, Penicillamine. Penicillamine is also sold under the brand name Depen.

In cases of rheumatoid arthritis, Cuprimine is used as a disease-modifying anti-rheumatic drug (DMARD). Cuprimine is believed to work by inhibiting several processes that contribute to autoimmune attacks.

How do I take it?
Cuprimine is taken orally once a day.

Cuprimine is available as a capsule.

Side effects... read more

The FDA-approved label for Cuprimine lists common side effects including changes to the sense of taste, mouth ulcers, nausea, diarrhea, vomiting, stomach pain, and loss of appetite.

Rare but serious side effects listed for Cuprimine can include drug fever, rash, and potentially fatal conditions such as blood disorders, myasthenia gravis, and Goodpasture’s syndrome.

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